Despite the success of deep learning on supervised point cloud semantic segmentation, obtaining large-scare point-by-point manual annotations is still a significant challenge. To reduce the huge annotation burden, we propose a Region-based and Diversity-aware Active Learning (ReDAL), a general framework for many deep learning approaches, aiming to automatically select only informative and diverse sub-scene regions for label acquisition. Observing that only a small portion of annotated regions are sufficient for 3D scene understanding with deep learning, we use softmax entropy, color discontinuity, and structural complexity to measure the information of sub-scene regions. A diversity-aware selection algorithm is also developed to avoid redundant annotations resulting from selecting informative but similar regions in a querying batch. Extensive experiments show that our method highly outperforms previous active learning strategies, and we achieve the performance of 90% fully supervised learning, while less than 15% and 5% annotations are required on S3DIS and SemanticKITTI datasets, respectively.